![]() ![]() Dexamethasone doses should be reduced when given with AKYNZEO.The inhibitory effect on CYP3A4 can last for multiple days The plasma concentrations of CYP3A4 substrates can increase when co-administered with AKYNZEO. Use with caution in patients receiving concomitant medications primarily metabolized by CYP3A4. Most common adverse reactions for AKYNZEO: headache, asthenia, dyspepsia, fatigue, constipation and erythema.Patients should be informed of the increased risk of serotonin syndrome, especially if AKYNZEO is used concomitantly with other serotonergic drugs. ![]() Patients should be monitored for the emergence of serotonin syndrome, and if symptoms occur, discontinue AKYNZEO and initiate supportive treatment. Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms: mental status changes, autonomic instability, neuromuscular symptoms, seizures, and gastrointestinal symptoms. Serotonin syndrome can be life threatening. Serotonin syndrome has been reported with 5-HT 3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs.Hypersensitivity reactions, including anaphylaxis, have been reported in patients receiving palonosetron, one of the components of AKYNZEO, with or without known hypersensitivity to other 5-HT 3 receptor antagonists.Important Safety Information Warnings and Precautions Limitations of UseĪKYNZEO for injection and AKYNZEO injection have not been studied for the prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy.ĪKYNZEO is a combination of palonosetron, a serotonin-3 (5-HT 3) receptor antagonist, and netupitant or fosnetupitant, substance P/neurokinin-1 (NK-1) receptor antagonists: palonosetron prevents nausea and vomiting during the acute phase and netupitant/fosnetupitant prevents nausea and vomiting during both the acute and delayed phase after cancer chemotherapy. (netupitant/palonosetron) capsules is indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy.ĪKYNZEO (fosnetupitant/palonosetron) for injection and AKYNZEO injection are indicated in combination with dexamethasone in adults for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. "Fosnetupitant and Palonosetron (Professional Patient Advice)"."Netupitant mixture with palonosetron".Archived from the original on 19 March 2020. ^ "Drug Approval Package: Akynzeo (fosnetupitant and palonosetron) Injection".^ "Drug Approval Package: Akynzeo (Netupitant and Palonosetron) Capsules NDA #205718".^ "Fosnetupitant / palonosetron (Akynzeo for Injection) Use During Pregnancy".Vienna: Österreichischer Apothekerverlag. Archived from the original on 24 January 2020. ^ a b "Drug Trials Snapshots: Akynzeo".Archived (PDF) from the original on 26 June 2016. ^ "Akynzeo: Summary of Product Characteristics" (PDF).Archived from the original on 1 February 2017. ^ "FDA approves Akynzeo for nausea and vomiting associated with cancer chemotherapy" (Press release).Archived from the original on 18 October 2020. ^ a b c d "Akynzeo- netupitant and palonosetron capsule Akynzeo- fosnetupitant and palonosetron injection".^ "Akynzeo 300 mg/0.5 mg hard capsules - Summary of Product Characteristics (SmPC)".: CS1 maint: archived copy as title ( link) Archived (PDF) from the original on 10 June 2022. ^ "Prescription medicines: registration of new chemical entities in Australia, 2015".Archived from the original on 9 September 2017. Therapeutic Goods Administration (TGA) (Report). ^ AusPAR: Netupitant / Palonosetron (as hydrochloride). ![]() Archived from the original on 19 December 2019.
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